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  • 1.  Labeling requirements for investigator initiated trials in US

    Posted 22-Sep-2020 07:54
    We are preparing a investigational new drug for investigator initiated trials in US, but it is difficult to labeling requirements for our investigational new drug.
    What I can find in FDA regulation site is only one sentence about it.
    Could you help me for labeling requirement for investigational new drug for IIT in US?



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    Inpyo Hong Mr.
    Seoul
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  • 2.  RE: Labeling requirements for investigator initiated trials in US

    Posted 22-Sep-2020 12:34
    Labeling of the Drug for investigational use:
    (21CFR312.6)
    • The immediate package of an investigational new drug intended for use shall bear a label with the statement "Caution: New Drug-Limited by Federal (or United States) Law to Investigational Use"  (This one sentence is mandatory)
    • The label or labeling of an investigational new drug may not bear any false or misleading statements or claim that is safe or effective
    If the following information is provided in the label, then you are good to go:
    Protocol #
    IND name/#: xxxxx 
    Product Name/strength, dosage form: xxx....mg/vial, or mg/tablets......etc
    Dosage Form/Route of administration: 

    Use according to the Protocol
    Storage Condition: 
    Caution: New Drug--Limited by Federal (or United States) Law to Investigational Use
    Name of the company/address​

    In addition, if your product requires special handling like "Do Not Shake" or Do not expose to light etc include it as well.

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    GRSAOnline
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  • 3.  RE: Labeling requirements for investigator initiated trials in US

    Posted 22-Sep-2020 20:41
    Dear Narayan,

    Thanks for your information, it is a great help to me. 
    It looks like that the labeling requirements is not define in regulation.
    The information you added is practical rule in the industry, isn't it? 
    In case of "Name of the company/address", does this information means the supplier of investigational new drug or manufacturer of this product?
    Our company is a small biotech company, so the manufacturer is other company (OEM manufacturer).
    So it is not proper to show the manufacturer name on it.
    Is it possible to written it as "supplier" or "provider" for "Name of the company" section on it?
    Thanks a lot.



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    InPyo Hong MS
    Seoul
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  • 4.  RE: Labeling requirements for investigator initiated trials in US

    Posted 23-Sep-2020 11:10
    The sponsor of the clinical trial address is recommended, since they should have all the information like manufacturer address, supplier address etc.....

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    GRSAOnline
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